Starters Tyrone Tracy, second on the team in receiving yards in 2019, and Charlie Jones, the 2021 Big Ten Returner of the Year, would both play 2022 with the Boilermakers.

[7] The Hawkeyes were ranked second in the West Division in the preseason Big Ten media poll, behind Wisconsin and ahead of Minnesota.

The Hawkeyes hosted Big Ten foes Michigan, Northwestern, Wisconsin, and Nebraska and traveled to Rutgers, Illinois, Ohio State, Purdue, and Minnesota.

[12] Roster Last update: 10/24/22 Iowa relied almost entirely on defense and special teams to earn a hard-fought victory over FCS foe South Dakota State.

The Jacks were only able to muster 120 total yards, in large part due to poor starting field position the entire day.

Iowa's Tory Taylor pinned SDSU inside their own 20 on 7 of his 10 punts, earning him B1G Special Teams Player of the Week honors.

[16][17][18] After enduring three separate lightning delays totaling 3 hours and 56 minutes, Iowa closed out their non-conference schedule with a 27-point win in the first meeting between the schools.

[19][20] In their B1G opener, Iowa scored two defensive touchdowns in the first half to pick up a win on the road and moved to 3–0 all-time versus Rutgers.

The Iowa offense turned the ball over six times and mustered just 158 yards and a field goal in what was the team's worst defeat since Kirk Ferentz's Big Ten debut in 1999.

Freshman kicker Drew Stevens had a banner day by kicking four field goals, including a 54-yarder – the 5th-longest (by distance) in school history.

[30][31][32] Purdue had won four of the previous five in this series, but the Hawkeye defense held the Boilermaker offense 190 yards and 30 points below their averages.