In their first playoff game at Ford Field, the Lions defeated their former quarterback Matthew Stafford and current quarterback Jared Goff's former team, the Los Angeles Rams 24–23 in the Wild Card game for their first playoff victory since the 1991 season, ending the longest winless post-season drought in the NFL.

To open the regular season, the Lions visited the defending Super Bowl champion Kansas City Chiefs in the annual NFL Kickoff Game.

The Lions took advantage of the Chiefs not having Travis Kelce, their star tight end, due to a knee injury sustained in their practice just two days prior to this game.

The Lions started off hot, scoring in the first quarter after a nine-yard touchdown pass from Jared Goff to Amon-Ra St. Brown.

The Seahawks scored 10 points in the third quarter, a three-yard touchdown run from Walker III, and a 25-yard field goal by Jason Myers.

The Seahawks came back in the fourth quarter via a three-yard touchdown pass from Geno Smith to Tyler Lockett and a 40-yard interception return by Tre Brown.

The Lions responded with a four-yard touchdown pass from Goff to Reynolds and a 38-yard field goal by Riley Patterson as time expired in the game to force overtime 31-31.

In the second quarter, the Panthers responded with a one-yard touchdown pass from Bryce Young to Tommy Tremble.

The Lions responded with a 27-yard touchdown pass from Jared Goff to Amon-Ra St. Brown, which made the score 10–3 in favor of Detroit at half-time.

After the defense forced Chicago into a three-and-out, the Lions scored again on a one-yard touchdown run from David Montgomery and a two-point conversion pass from Goff to Sam LaPorta.

On the Bears' next possession, a fumble forced by Aidan Hutchinson led to a safety, making the final score 31–26 in favor of Detroit.

For their annual Thanksgiving Day game, the Lions hosted their divisional rival, the Green Bay Packers, in a rematch of week 4.

The Lions scored six points in the quarter via a seven-yard touchdown pass from Jared Goff to Sam LaPorta.

The Bears scored 10 points in the first quarter via a 16-yard touchdown run from D. J. Moore and a 46-yard field goal by Cairo Santos.

The Broncos scored ten points in the third quarter via a three-yard touchdown pass from Russell Wilson to Lil'Jordan Humphrey and a 23-yard field goal by Wil Lutz.

The Lions scored ten points in the second quarter via a 37-yard field goal by Michael Badgley and a 14-yard touchdown run from Jahmyr Gibbs.

The Lions responded with a one-yard touchdown pass from Jared Goff to Amon-Ra St. Brown to regain the lead.

Ifeatu Melifonwu intercepted a Mullens pass at the Lions' five-yard line with 58 seconds remaining in the game that sealed the victory.

The Cowboys scored ten points in the quarter via an eight-yard touchdown pass from Prescott to Brandin Cooks and a 43-yard field goal by Aubrey.

A momentum shift occurred when Cowboys tight end Peyton Hendershot tripped Aidan Hutchinson.

The Lions attempted a two-point conversion again from the seven-yard line with Goff throwing an interception, but the Cowboys were penalized for offsides.

In a last-ditch effort, the Lions attempted an onside kick but failed to recover the ball, and the Cowboys ran out the clock, securing a 20–19 victory.

To end the regular season, the Lions hosted their divisional rival, the Minnesota Vikings, in a rematch of week 16.

To start the postseason, the Lions hosted the Los Angeles Rams, in the first ever playoff game at Ford Field.

The Lions responded with a two-yard touchdown pass from Jared Goff to Sam LaPorta, which made the score 21–17 in favor of Detroit at half-time.

The Lions regained the lead in the second quarter via a nine-yard touchdown pass from Jared Goff to Josh Reynolds.

The Buccaneers responded with a 16-yard touchdown pass from Mayfield to Mike Evans and a failed two-point conversion attempt.

The Buccaneers' attempted comeback failed after Mayfield's pass was intercepted by Derrick Barnes with 1:35 remaining in the game, securing the Lions' victory.

The Lions added ten points in the quarter via a 15-yard touchdown run from Jahmyr Gibbs and a 21-yard field goal by Michael Badgley, which made the score 24–7 in favor of Detroit at halftime.

The 49ers scored ten points in the fourth quarter via a 33-yard field goal by Moody and a three-yard touchdown run from Elijah Mitchell to take their first lead of the game.