The 2022 Italian general election took place on 25 September 2022.

In its two single-seat constituencies, Aosta Valley elected Franco Manes (Valdostan Union within the Aosta Valley coalition) to the Chamber of Deputies and Nicoletta Spelgatti (Lega Vallée d'Aoste within the centre-right coalition) to the Senate of the Republic.

Spelgatti, a former president of Aosta Valley, was the first Valdostan woman elected to the Senate.