The Wildcats played their home games at Kroger Field in Lexington, Kentucky, and competed in the Eastern Division of the Southeastern Conference (SEC).

They were led by tenth-year head coach Mark Stoops.

On August 2, 2024, the NCAA announced that the University of Kentucky has agreed to accept penalties for violations of impermissible benefits as 11 football players were paid for jobs which they did not perform in the 2021 and 2022 seasons.

Although the NCAA has not announced the full penalties, it has been indicated by the university that those penalties will include a 2–year probation and vacation of all games in which the ineligible players participated for those two seasons.

[1] Kentucky and the SEC announced the 2022 football schedule on September 21, 2021.