After using ranked ballots in the 2018 municipal election, London returned to using the first past the post electoral system after the passing of the Supporting Ontario's Recovery and Municipal Elections Act, 2020 by the Government of Ontario, which removed the right of municipalities to use a different electoral system from FPTP.

[3] Two days later, deputy mayor Josh Morgan announced he was running for the position.

On June 27, former Liberal MPP Khalil Ramal announced he would run for mayor.

[5] On the final day of registration, August 19, well-known local pastor Sandie Thomas entered the race.

[6] Social media personality Dylan Wallace attempted to join the race, but did not register before the deadline to be on the ballot.