The 2022 Louisville Cardinals men's soccer team represented the University of Louisville during the 2022 NCAA Division I men's soccer season.

The Cardinals were led by head coach John Michael Hayden, in his fourth season.

They received an at-large bid to the NCAA Tournament where they lost in the First Round to Western Michigan to end their season.

They received an at-large bid to the NCAA Tournament where they lost in the First Round to Bowling Green to end their season.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.