The entire tournament was held at Rocket Mortgage FieldHouse, in Cleveland, Ohio between March 9 and 12.

[1] Second seeded Buffalo won the tournament with a 79–75 win over Ball State.

[3] As with the 2021 MAC women's basketball tournament only the top 8 finishing teams qualify and all games were played on a neutral court.

The 2022 MAC tournament was held at Rocket Mortgage FieldHouse for the 22nd consecutive season.

Teams were seeded by record within the conference, with a tiebreaker system to seed teams with identical conference records.