The 2022 MPBL All-Star Game was also held at the Batangas City Coliseum on October 2.
The playoffs then began on October 15 and ended on December 12 when the Nueva Ecija Rice Vanguards defeated the Zamboanga Family's Brand Sardines in four games in the 2022 MPBL finals.
[5] On November 9, 2021, the MPBL announced that the league would be given professional status, which was granted by the Games and Amusement Board one month later.
[6] League commissioner Kenneth Duremdes then announced that the season opener is once again postponed to 2022.
To make up for the long gap, Duremdes also announced that an invitational tournament would be held in December 2021 to help teams prepare for the then-upcoming season.
The Basilan Steel and Davao Occidental Tigers moved to other leagues while the Bicol Volcanoes, Bulacan Kuyas, Cebu Casino Ethyl Alcohol, Navotas Uni-Pak Sardines, Iloilo United Royals, Parañaque Patriots, and Pasay Voyagers all became inactive.
Philip Manalang was awarded the Finals MVP after making a game-winning buzzer beater to lift Basilan over the Nueva Ecija Rice Vanguards, 83–80.
Cedric Ablaza of the Batangas City Embassy Chill and Mark Yee of Bacolod Bingo Plus earned their third all-star selections while Michael Mabulac of the Nueva Ecija Rice Vanguards, Cris Masaglang of the GenSan Warriors, and Leo Najorda of the Imus City Bandera made their second all-star appearances.
Returning events include the Three-Point Shootout and Slam Dunk Contest.
Due to the expiration of ABS-CBN's franchise, the league had to award the television broadcast rights to another network.
Thus, this season marked the first year of the league's ongoing broadcast rights with Cignal TV, as the games were split between the free-to-air One PH and cable channel One Sports+.