The 2022 Mid-Season Invitational was the seventh Mid-Season Invitational (MSI), a Riot Games–organised tournament for League of Legends, a multiplayer online battle arena video game.

The tournament was the culmination of the 2022 Spring Split and the first interregional competition of Season 12.

11 of the 12 premier League of Legends leagues had a team representing them; the LCL was not participating due to the Spring Split being cancelled as a result of the 2022 Russian invasion of Ukraine.

[4] Defending champion Royal Never Give Up from China defeated T1 from South Korea 3–2 in the final, winning their third MSI title.

Due to the ongoing Russian invasion of Ukraine, the LCL Spring Split had been cancelled, and the CIS region therefore could not participate in the tournament.