The 2022 Northwestern State Lady Demons softball team represented Northwestern State University during the 2022 NCAA Division I softball season.

The Lady Demons played their home games at Lady Demon Diamond and were led by fourteenth year head coach Donald Pickett.

The Southland Conference Coaches Poll was released on February 4, 2022.

Northwestern State was picked to finish second in the Southland Conference with 120 votes and 2 first place votes.

[2] [3] [4][5] Donald Pickett (UT Chattanooga) Lexi Smith (Texas A&M) Roster Last update: 27 June 2022 *Rankings are based on the team's current ranking in the NFCA/USA Softball poll.