The 2022 McNeese State Cowgirls softball team represented McNeese State University during the 2022 NCAA Division I softball season.

The Cowgirls played their home games at Joe Miller Field at Cowgirl Diamond and were led by sixth-year head coach James Landreneau.

The Southland Conference Coaches Poll was released on February 4, 2022.

McNeese State was picked to finish first in the Southland Conference with 132 votes and 12 first place votes.

[2] [3] [4] James Landreneau (McNeese State) Shellie Landry (Louisiana)Alyssa Denham (Arizona)Cori McCrary (McNeese State) Roster Last update: 18 June 2022 *Rankings are based on the team's current ranking in the NFCA/USA Softball poll.