The 2022 Oklahoma Sooners baseball team represented the University of Oklahoma during the 2022 NCAA Division I baseball season.

The Sooners played their home games at L. Dale Mitchell Baseball Park as a member of the Big 12 Conference.

They were led by head coach Skip Johnson, in his 5th season at Oklahoma.

In the 2021 Big 12 Conference baseball tournament, the fifth-seeded Sooners fell to fourth-seeded Oklahoma State 5–9 and top-seeded Texas 1–4 to end their conference tournament in the First Round.

The Sooners did not earn an at-large bid to the 2021 NCAA Division I baseball tournament.