The 2022 Ole Miss Rebels football team represented the University of Mississippi in the 2022 NCAA Division I FBS football season.

The Rebels played their home games at Vaught–Hemingway Stadium in Oxford, Mississippi, and competed in the Western Division of the Southeastern Conference (SEC).

They were led by third-year head coach Lane Kiffin.

Ole Miss and the SEC announced the 2022 football schedule on September 21, 2021.

[1][2] at Vaught–Hemingway Stadium • Oxford, MS at Vaught–Hemingway Stadium • Oxford, MS at Bobby Dodd Stadium • Atlanta, GA at Vaught–Hemingway Stadium • Oxford, MS at Vaught–Hemingway Stadium • Oxford, MS at FirstBank Stadium • Nashville, TN at Vaught–Hemingway Stadium • Oxford, MS at Tiger Stadium • Baton Rouge, LA at Kyle Field • College Station, TX at Vaught–Hemingway Stadium • Oxford, MS at Donald W. Reynolds Razorback Stadium • Fayetteville, AR at Vaught–Hemingway Stadium • Oxford, MS at NRG Stadium • Houston, TX