The 2022 Oregon Ducks softball team represented the University of Oregon during the 2022 NCAA Division I softball season.

The Ducks, led by 4th-year head coach Melyssa Lombardi, played their home games at Jane Sanders Stadium as members of the Pac-12 Conference.

Last season, the Ducks finished the season with a 14–10 record in conference play and a 40–17 overall record.

[2] In the postseason, the Ducks were invited and participated in the 2021 NCAA Division I softball tournament, where they lost to Texas State and the #12 national seed Texas in the Austin Regional in Austin, Texas.

[3][4] Pitchers Catchers Infielders Outfielders Note: Season counter accounts for all stints at Oregon.