Played between six teams in a double round robin format with strict COVID-19 protocols, the league began on 27 January 2022 with the first phase taking place in Karachi.

[2] Shahid Afridi had stated PSL 2022 would be his farewell season but on 13 February, he withdrew mid-season due to injury.

[9] On 24 July 2021, PCB announced that the seventh season of PSL will be held in January and February 2022 with all matches taking place in Pakistan.

[13] On 30 December 2021, National Command and Operation Center issued that only fully vaccinated people will be allowed to gather at the stadiums, after potentially lifting the restrictions of COVID-19 pandemic in Pakistan.

[15] On 19 January 2022, NCOC banned the entry for kids under age of 12 as they were not eligible for vaccination yet, and issued that only 25 percent crowd will be allowed in the Karachi phase.

[17] On 5 January, it was reported that all matches will be played as per schedule under strict standard operating procedures, though the officials were worried about a surge in SARS-CoV-2 Omicron variant,[21] as they neither wanted to shift the league to UAE,[22] nor wanted to postpone due to a packed international schedule of Pakistan cricket team.

[40] In response to the broadcast rights, Aitzaz Ahsan told that Lahore High Court dismissed the petitions filed by Geo TV; one against PCB's bidding process and the other against PTV-ARY joint venture.

[45] The anthem titled "Agay Dekh", sung by Atif Aslam and Aima Baig, was released on 24 January.

[48][49] The curtain closer took place on 27 February, where trophy was revealed by Red Bull drift driver Abdo Feghali, and Hadiya Hashmi performed Qaumi Taranah.

[63] Fakhar Zaman scored the first century of the season in game six, helping the Lahore Qalandars to a 6 wicket win over Karachi.

[70] On the same day, Tim David scored the second fastest half century in PSL history, as Multan beat Peshawar by 57 runs.

[73] The Lahore leg started with another win for the Multan Sultans, this time by 42 runs over Peshawar, which later meant they qualified for the play-offs.

[75] Sarfaraz Ahmed led from the front in game eighteen, he scored an unbeaten half century to steer Quetta to a 5 wicket win over Islamabad.

Waqas Maqsood took 2 wickets in the final over and ran out Chris Jordan to give Islamabad United a 1 run win.

[80] The next day, Mohammad Rizwan scored 76 to give Multan a 7 wicket win and hand Karachi their eighth consecutive loss.

[81] Mohammad Haris scored his first PSL half century in game twenty four, helping Peshawar to a 10 run win over Islamabad.

[82] Multan scored the highest total of the tournament in game twenty five, resulting in a 117 run win over Quetta.

[87] Shaheen Shah Afridi's cameo of 39 with the bat sent the final game of the league stage to a super over against Peshawar.

His opposing captain Wahab Riaz bowled an economical super over though, conceding 5 runs to help Peshawar Zalmi finish the league stage off with a win.

In the last over, Liam Dawson hit two consecutive boundaries off Benny Howell to seal a 5 wicket win for Islamabad.

Shafique was supported by contributions from Kamran Ghulam, Mohammad Hafeez and David Wiese which allowed Lahore to finish on 168/7.