The 2022 División Intermedia season, named "Homenaje al Doctor Luis Lezcano Pastore y al Escribano Julio César Ortiz Duarte", was the 104th season of the second-tier league of Paraguayan football and 25th under the Paraguayan División Intermedia name.
[2] Sportivo Trinidense and Sportivo Luqueño ensured their promotion to the Paraguayan Primera División with two matches in hand; the former by drawing 1–1 with 2 de Mayo at home on 25 September 2022,[3] while the latter clinched promotion with a 1–0 victory against Atlético Colegiales coupled with a 2–0 loss for Pastoreo against Fernando de la Mora the following day.
[4] Sportivo Trinidense ended up clinching the tournament's title the following weekend, with a win over Atlético Colegiales and a loss for Sportivo Luqueño against San Lorenzo.
The top two teams at the end of the season were promoted to the Paraguayan Primera División for the 2023 season, while the bottom three teams in the relegation table at the end of the season were relegated: teams located within 50 kilometres of Asunción were relegated to Primera División B, while teams from outside Greater Asunción and the Central Department were relegated to Primera División B Nacional.
[1] 16 teams competed in the season: 11 teams from the previous División Intermedia season plus the two teams relegated from Primera División in its 2021 season (River Plate and Sportivo Luqueño), the top two teams from the 2021 Primera División B (Atlético Colegiales and Martín Ledesma) and the 2019–20 Campeonato Nacional de Interligas champions Pastoreo.