The competition began on 10 May and ended on 10 November 2022, with the winners qualifying for the 2023 Copa Sudamericana as well as the 2022 Supercopa Paraguay against the Primera División champions with better record in the aggregate table.
Sportivo Ameliano won their first Copa Paraguay title, beating Nacional on penalty kicks after a 1–1 draw in regular time in the final.
[3] Ties in all subsequent rounds were played on a single-legged basis, with a penalty shootout deciding the winner in case of a draw.
The 2022 edition had a total of 74 participating teams: The champions from each of the 17 departments of Paraguay qualified for the competition: The draw for the first stage was held on 22 April 2022 and matches were played from 10 May to 17 June 2022.
[11] On 14 October 2022, the APF confirmed that the final would be played in Encarnación on 4 November 2022, as the opening event of the newly built Estadio Villa Alegre.