The National League will adopt the designated hitter full-time, a draft lottery will be implemented, the postseason will expand from ten teams to twelve, and advertising patches will appear on player uniforms and helmets for the first time.

[9][10] The Phillies began their bullpen overhaul on November 5, 2021, when they claimed left-handed relief pitcher Ryan Sherriff off of waivers from the Tampa Bay Rays.

Although Nola allowed a three-run home run in the seventh inning, the lineup continued to score, and the Phillies won 9–6 to start the season.

[36] Kyle Gibson started the next game on April 9, earning the win as he struck out 10 batters for only the fourth time in his MLB career.

[39] In the fourth game of the season, third baseman Alec Bohm made three fielding errors over three innings and was seen saying "I fucking hate this place.

[39] In early April reigning MVP, Bryce Harper began experiencing pain in his throwing elbow preventing him from playing in the outfield.

[39] On May 22, the Phillies played the Dodgers, this time at Citizens Bank Park, and won 4–3 on a walkoff error by second baseman Max Muncy.

[39] In the series finale against the Angels, on June 5, the Phillies were down 6–2 in the 8th inning, but Bryce Harper tied the game up at 6 runs each with a grand slam.

[39] To make room for the acquisitions, the Phillies released struggling veteran players including relief pitcher Jeurys Familia, centerfielder Odubel Herrera and shortstop Didi Gregorius.

Having lost five straight games, the Phillies, led by the efforts of centerfielder Matt Vierling, completed a come from behind win against the Toronto Blue Jays, on September 21, to remain in the playoff hunt.

[39] The game was scoreless until the seventh inning, when Juan Yepez hit a pinch-hit two-run home run off of Jose Alvarado, who had just relieved Wheeler.

The score was still 2–0 in the top of the ninth when Cardinals closer Ryan Helsley, who had jammed fingers on his throwing hand in his previous appearance, allowed a single and two walks, then hit Alec Bohm with a 101-mph fastball, giving the Phillies their first run.

[39] Realmuto became the first catcher in Major League Baseball history to hit an inside-the-park home run in the postseason, giving the Phillies a 4–1 lead.

[39] The Phillies faced the San Diego Padres, who also reached the playoffs via a Wild Card berth, in the 2022 National League Championship Series.

[39] In the ninth inning, a potential game-ending double play was spoiled when Bryson Stott missed a throw by third baseman Alec Bohm off of a Juan Soto grounder.

Stott threw to second baseman Jean Segura, who dropped the ball, allowing Soto to score and tie the game at one run a piece.

[39] However, in the bottom of the fourth inning, Segura redeemed himself with a two out base hit to right field scoring Bohm and Stott to give the Phillies a 3–1 lead over the Padres.

[39] In the bottom of the third with two outs, Darvish walked Schwarber and the next batter, Hoskins, followed up on his performance in Game 4, and hit a two-run home run on a 3–0 pitch.

With two outs and two strikes on the batter, Trent Grisham, Dominguez threw another pitch in the dirt to score Azócar and give San Diego the lead.

[39] After Domínguez's disappointing performance in the seventh inning, he was replaced by Alvarado, who walked Soto after giving up a single to Jurickson Profar.

[39] The Astros got out to an early start led by Kyle Tucker, who hit a solo home run off of Nola in the bottom of the second inning.

[39] In the bottom of the ninth inning, with a runner on second base and two outs, Jeremy Peña hit a blooper to right field, which Castellanos caught on a slide to keep the Astros from winning.

[39] In the top of the tenth inning, Realmuto hit a solo home run off Luis García to give the Phillies a one-run lead.

[39] In the bottom of the tenth inning, David Robertson struck out Yordan Alvarez before giving up a double to Alex Bregman.

[39] Bernie Parent, Mike Schmidt, Julius Erving, and Brandon Graham, championship winning athletes for all four professional teams in Philadelphia, threw ceremonial first pitches.

Connor Brogdon, Kyle Gibson, Nick Nelson, and Andrew Bellatti each pitched a scoreless inning to complete the shutout as the Phillies won 7–0.

[39] Before Game 5, rapper and Philadelphia native Meek Mill performed his song Dreams and Nightmares and rode with the Phillie Phanatic on his ATV.

In the bottom of the eighth inning, Castellanos scored on an RBI single by Jean Segura narrowing the Phillies' deficit and putting runners on the corners.

[39] In the ninth inning, Chas McCormick made a leaping catch at the right-center wall on a flyball hit by J. T. Realmuto for the second out, preventing a likely double or triple.

Young players, who have proven they belong; an incredible core of All-Star veterans; a manager, who knows how to get the best from us; a front office and ownership, who would do whatever it takes and the best home field advantage in baseball.