The 2022 Pit Boss 250 was the sixth stock car race of the 2022 NASCAR Xfinity Series and the second iteration of the event.

The race was held on Saturday, March 26, 2022, in Austin, Texas, at the Circuit of the Americas, a 3.426 miles (5.514 km) permanent road course.

Circuit of the Americas (COTA) is a grade 1 FIA-specification motorsports facility located within the extraterritorial jurisdiction of Austin, Texas.

The facility is home to the Formula One United States Grand Prix, and the Motorcycle Grand Prix of the Americas, a round of the FIM Road Racing World Championship.

* Denotes entry has withdrawn from the event The only 30-minute practice session was held on Friday, March 25, at 4:00 PM CST.