The 2022 Route d'Occitanie (known as the La Route d'Occitanie - La Dépêche du Midi for sponsorship reasons) is a road cycling stage race that took place between 16 and 19 June 2022 in the southern French region of Occitanie.

The race is the 46th edition of the Route d'Occitanie and is rated as a category 2.1 event on the 2022 UCI Europe Tour.

Nine UCI WorldTeams, seven UCI ProTeams, and five UCI Continental made up the twenty-one teams that participated in the race.

[1] UCI WorldTeams UCI ProTeams UCI Continental Teams