The 2022 Saint John's Johnnies football team represented Saint John's University as members of the Minnesota Intercollegiate Athletic Conference (MIAC) during the 2022 NCAA Division III football season.
Led by ninth-year head coach Gary Fasching, the Johnnies compiled an overall record of 10–2 with a mark of 7–1 in conference play, winning the MIAC Northwoods Division title.
Saint John's defeated Bethel in the MIAC Championship Game to win the conference title and earn an automatic bid to the NCAA Division III Football Championship playoffs.
The team played home games at Clemens Stadium in Collegeville, Minnesota.
Saint John's 2022 regular season scheduled consisted of five home and four away games.