Mary Hardin–Baylor, the defending national champions, were the top-ranked team to begin the season.
The season's playoffs were played between November 19 and December 16, culminating in the national championship—also known as the Stagg Bowl—at the Navy–Marine Corps Memorial Stadium in Annapolis, Maryland.
In addition to the above, the USA South amicably split into two conferences at the end of the 2021–22 school year.
Belhaven, which had previously been announced as a new USA South all-sports member for 2021–22, instead joined CCS.
This meant the only changes to USA South football were the arrival of Belhaven and departure of Averett.