[1] On 3 May 2022, the cities of Alcoy, Benidorm and Elda were added as the other play-off venues.
Each of the five groups of the Segunda División RFEF were represented by the four teams that finished the regular season between the second and fifth positions.
[3] In the draw for the first stage, the participating teams were assigned to pots corresponding to their final regular season position.
[5] The final two relegation spots (of 27 total) were also determined via play-offs.
The four 13th-place finishers with the lowest point totals were drawn into two single-leg matches, with the winners securing survival in the Segunda División RFEF and the losers being relegated to the Tercera División RFEF.