On 15 June, center Nikola Jokić, who was named the NBA Most Valuable Player Award for the 2021–22 season, has confirmed that he will play at the EuroBasket.

[16] On 3 August, head coach Pešić announced that NBA players Pokuševski and Nikola Jović are cut from the roster due to disapproval of their clubs, the Oklahoma City Thunder and the Miami Heat respectively.

On 1 September, center Nikola Milutinov was reported injured due to health issues, missing a team departure to Prague.

Guards Ognjen Jaramaz and Vanja Marinković, forwards Dejan Davidovac and Marko Jagodić-Kuridža, as well as center Dušan Ristić made their debuts at a major tournament.

[28] The following were candidates to make the team: Head coach Pešić won two EuroBasket editions, with Germany in 1993 and with FR Yugoslavia in 2001.

The team is scheduled to play at the 2022 Supercup Hamburg tournament together with Germany, Italy, and the Czech Republic from 19 to 20 August 2022.

[38] The match with Montenegro on 13 August in Belgrade was played behind closed doors and it started with a moment of silence for the victims of Cetinje shooting from the day before.

[23] A Dutch forward Worthy de Jong played one of the best games of his career, getting 28 points for the Netherlands, but Serbia had another gear in them and were unfazed en route to a winning start, a 100–76 victory in front of a large group of their fans in Czech Republic.

The main reason for Serbia never losing their composure was the fact they have center Nikola Jokić and guard Vasilije Micić in their ranks.

Both stars played outstanding games to safely guide Serbia to a first win ahead of their match-up with the group hosts on Saturday.

Guard Micić was impressive with a 15-point, 12-assist double-double, while Jokić finished with 19 points, 6 rebounds and 4 assists, sitting out the entire fourth quarter.

Guard Vanja Marinković had five threes and 18 points, center Dušan Ristić and forward Nikola Kalinić were also in double figures, all 11 players played and all 11 of them scored.

The Netherlands made Serbia work, and Worthy de Jong scored 28 points in 27 minutes, done on 11-of-14 shooting from the field.

[54][55] 0 Center Nikola Milutinov was out of the Serbian roster due to health issues,[23] as well as a Czech guard Tomáš Satoranský.

It was always going to be an uphill battle for Czech Republic, and after learning that their captain Tomáš Satoranský would not suit up for the game against Serbia, it got tougher.

Backed by the crowd in the sold-out arena in Prague, the hosts were holding on in the first quarter, ending it with a five point deficit.

However, Serbia's next huddle proved to be the winning one, as head coach Pešić found the panacea for the poison already after 10 minutes.

Serbian center Jokić was unstoppable, recording 18 points in 25 minutes of playing time, done on 7-of-11 shooting from the field, with 11 rebounds, 5 assists and 2 steals.

[55] 0 Guard Vanja Marinković was out of the Serbian roster due to stomach issues, while center Nikola Milutinov returns.

[62] Backed by their 5,000 traveling fans and led by their NBA star, Lauri Markkanen, Finland hoped they could make life difficult for Serbia on Monday.

Serbian coach Svetislav Pešić showed a masterful display of out-pacing Finland, matching their intensity by going even harder after them, and balancing out the minutes and roles for all his players.

Their biggest lead was by 18 points, however Israeli Deni Avdija (also holding Serbian citizenship) decided to make things interesting.

Serbian guard Ognjen Jaramaz exploded and collected 10 points, guiding Serbia back towards double digit lead, and ultimately to their fourth win in four tries.

Serbian center Nikola Jokić sat out the fourth quarter, and still was the best player in a 96–69 win over Poland on Thursday that concluded group action.

Poland was trailing by 13 early on in the third quarter, but a timeout by coach Svetislav Pešić resulted in Serbia pulling away decisively for a 25-point lead by the end of the period.

One summer after surprising Serbia in the Final of the 2020 FIBA Olympic Qualifying Tournament in Belgrade to reach the Tokyo Games, Italy worked their team basketball magic again – and doing it without head coach Gianmarco Pozzecco who was ejected in the third quarter.