Trailing 21–15 with less than two minutes remaining in their final game against Wales, Edoardo Padovani scored a try to win the match for Italy, ending a 40-match winless run in the Six Nations.

[4] 1 Owen Farrell was originally named in the England squad as captain ahead of the Championship, but was later ruled out due to injury.

2 Fabien Galthié tested positive for COVID-19 ahead of the opening round and Raphaël Ibañez took on the role for France's match against Italy.

Table ranking rules The tournament's fixtures were announced on 28 April 2021, and included a Friday night game – Wales hosting France in round 4 – for the first time since the opening match of the 2019 Six Nations Championship.

In the United Kingdom, each game was broadcast live on a free-to-air terrestrial TV channel, either the BBC or ITV, as a result of a new deal covering the four years from 2022 to 2025.