In September 2017, Camilo Pérez López Moreira, president of the Paraguayan Olympic Committee, reported that he had the endorsement of then-President Horacio Cartes to be able to present the Asunción 2022 candidacy.

Asunción was finally the only city that officially presented its candidacy for the 2022 South American Games before the nominations deadline, on 17 November 2019.

Among the venues that were designed for the event were the Paraguayan Olympic Park, the Sportivo Luqueño Club (both located in Luque), the bay of Asunción and Rakiura, while the South American Village was built in the city of Mariano Roque Alonso in an area of 17.5 hectares (although it was initially indicated that it would be in Costanera Norte).

The reason given by the government was that the resources committed in the Games were destined to the construction of a new hospital in Barrio Obrero and other health projects.

On 8 October, the president of Odesur and also of the Paraguayan Olympic Committee, Camilo Pérez, announced that Asunción will finally organize this edition of the South American Games.