The 2022 South Florida Bulls football team represented the University of South Florida (USF) during the 2022 NCAA Division I FBS football season.

The Bulls played their home games at Raymond James Stadium in Tampa, Florida.

Third-year head coach Jeff Scott was fired after nine games and a 1–8 start; special teams coordinator Daniel Da Prato finished out the season.

Also like 2020, they went winless in conference play, and did not win a single game against an FBS opponent.

[1] Jeff Scott went 4-26 during his 3 years as South Florida's head coach with only one win against an FBS opponent, both the worst in school history.