The 2022 Strade Bianche Donne was an Italian road cycling one-day race that took place on 5 March 2022.

It was the 8th edition of Strade Bianche Donne and the first event of the 2022 UCI Women's World Tour.

[3] The final kilometre in Siena to the finish line in the Piazza del Campo has a maximum gradient of 16%.

On the final climb on the Via Santa Caterina up to the finish, Lotte Kopecky of SD Worx was the only rider able to keep up with Annemiek van Vleuten of Movistar Team.

[2] After the race, Kopecky lauded the work of her SD Worx teammates.