The 2022 Texas Southern Tigers football team represented Texas Southern University a member of the West Division of the Southwestern Athletic Conference (SWAC) during the 2022 NCAA Division I FCS football season.

Led fourth-year head coach Clarence McKinney, the Tigers compiled an overall record of 5–6 with a mark of 4–4 in conference play, tying for third place in the SWAC's West Division.

Texas Southern played home games at BBVA Compass Stadium in Houston.

Texas Southern finalized their 2022 schedule on February 26, 2022.

This college football 2020s season article is a stub.