The 2022 Jackson State Tigers football team represented Jackson State University as a member of the East Division of the Southwestern Athletic Conference (SWAC) during the 2022 NCAA Division I FCS football season.

Led by third-year head coach Deion Sanders, the Tigers played their home games at Mississippi Veterans Memorial Stadium in Jackson, Mississippi.

Jackson State won their second straight SWAC East Division championship and their second straight SWAC title under Sanders leadership, finishing the regular season undefeated, 12–0.

The Tigers played MEAC champion North Carolina Central in the 2022 Celebration Bowl in Atlanta, and lost.

Sanders resigned as the team's head coach after winning the SWAC championship on December 3, 2022 to become the head coach at Colorado.