In the Moto2 class, the now retired Gabriel Rodrigo continues to be replaced with Taiga Hada in the Pertamina Mandalika SAG Team.

In the Moto3 class, in addition to Nicola Carraro who continues to substitute the injured Matteo Bertelle in the QJmotor Avintia Racing Team, there is a new replacement in the Rivacold Snipers Team against the convalescent Alberto Surra: it is Vicente Pérez, who had not raced in this category since the 2019 Catalan Grand Prix.

Fabio Quartararo, taking advantage of Francesco Bagnaia's fall and Aleix Espargaró's arrival out of the points zone in the previous race, increases his advantage in the riders' classification, which he leads with 219 points, to +18 and +25 compared to the Italian respectively and some Spanish.

The victory in the home Grand Prix by Ai Ogura ahead of Augusto Fernández allows the Japanese to reduce the gap to two points from the top of the riders' standings (234 points for Fernández, 232 for Ogura).

Arón Canet and Celestino Vietti lose ground, both fallen in Motegi: now they are 57 and 72 points behind the summit.