The team was founded in 2010 by the former Grand Prix motorcyclist Luca Boscoscuro and entered the newly formed Moto2 class of the world championship.

In the team's first year they achieved three wins with their S10 motorcycle, based on a FTR Moto M210 frame,[1] ridden by Andrea Iannone and Gábor Talmácsi.

Lowes finished the season as the only non-Kalex rider in the top 14 of the final championship standings, in 4th place in the year-end table, having won at the Circuit of the Americas.

In 2016 saw Speed Up's own team line up with a new rider in Simone Corsi, with Lowes having left to join Gresini Racing in 2016 with a following MotoGP contract for 2017.

In 2021, with a view to differentiating the racing team from the chassis production, the motorcycle prototype frames produced were renamed under the brand Boscoscuro.