[3] As a result, the team owners voted unanimously to lockout the players stopping all free agency and trades.
The National League will adopt the designated hitter full-time, a draft lottery will be implemented, the postseason will expand from ten teams to twelve, and advertising patches will appear on player uniforms and helmets for the first time.
The Blue Jays gained compensation selections at the end of the second round due to Robbie Ray and Marcus Semien signing with the Seattle Mariners and Texas Rangers respectively.
After falling behind 7–0 in the fourth inning, Toronto launched the largest comeback victory on Opening Day in 72 years, winning 10–8.
The Blue Jays won the first game of the four-game set, 3–0, and Jordan Romano earned his 26th consecutive save, breaking Tom Henke's franchise record.
[24] Toronto began a six-game road trip in Boston the following night, where Bo Bichette's first two errors of the season helped the Red Sox to a 2–1 win.
[27] In the first game of a three-game series against the Houston Astros, Matt Chapman's ninth-inning double drove in Vladimir Guerrero Jr. to give the Blue Jays a 4–3 victory.
[30] On April 25, the Blue Jays returned to Toronto to begin a ten-game homestand, starting with four games against the Red Sox.
[33] The Blue Jays took the series victory with a 1–0 win in the final game, led by Alek Manoah's seven shutout innings.
[44] The Jays ended their losing streak with a 5–1 victory in the second game, before dropping their fourth straight series with a 3–0 loss in the finale.
Home runs from Bo Bichette and Matt Chapman led the Jays to a 6–2 win in the opener against the Mariners.
[48] The Blue Jays had another opportunity for a sweep, taking the first two games against Cincinnati by scores of 2–1 and 3–1, but again lost the finale, 3–2, after Toronto native Joey Votto's first home run of the season gave the Reds the lead.
[52] The Blue Jays rallied in the ninth inning of the second game, with Lourdes Gurriel Jr.'s RBI single proving to be the difference in a 4–3 victory.
[55][56] The Blue Jays began June by completing a three-game sweep of the White Sox at home, and winning their eight consecutive game.
[58] From July 2 to 10, the Blue Jays lost nine of ten games, culminating in a three-game sweep at the hands of the Seattle Mariners at T-Mobile Park.
Prior to the second game, the Blue Jays held a pre-game ceremony honouring members of the 1992 World Series Championship team for a 30th anniversary celebration.