Qualifying for the championship was open to any professional or amateur golfer who was 50 years of age or over on the start of the tournament on 25 August 2022, however restricted by a certain handicap level.

The final field of 120 players, 37 amateurs and 83 professionals, included 2021 champion Annika Sörenstam.

[4][5][6] Eleven countries were represented in the field – Australia (2), Canada (6), England (4), France (1), India (1), Italy (1), Japan (7), Peru (1), Scotland (2), Sweden (5) and United States (90).

From the 2021 U.S. Senior Women's Open Championship, the amateur(s) returning the lowest 72-hole score: 4.

Any professional or applicant for reinstatement who has won the U.S. Women's Amateur Championship (three-year exemption): 7.

Playing members of the two most recent United States and Great Britain & Ireland Curtis Cup Teams, and the two most current United States Women's World Amateur Teams (must be an amateur) 11.

From the 2021 LPGA Teaching & Club Professional Championship (Senior Division), the three lowest scores and ties: 17.

From the final 2021 LPGA Tour all-time money list, the top 10 age-eligible players not otherwise exempt as of February 16, 2022: 20.

Playing members of the five most recent United States and European Solheim Cup Teams 22.