[6] Eintracht Frankfurt won the match 5–4 on penalties, following a 1–1 draw after extra time, for their second UEFA Cup/Europa League title after 1980.

The city of Seville hosted the 2003 UEFA Cup final at the Estadio de La Cartuja.

[11] The following associations expressed interest in hosting but eventually did not submit bids: The Ramón Sánchez Pizjuán was selected by the UEFA Executive Committee during their meeting in Ljubljana, Slovenia on 24 September 2019.

Having become the first German team in a major European final since Bayern Munich in the 2020 UEFA Champions League final and the first UEFA Cup/Europa League finalist from Germany since Werder Bremen in 2009, they were seeking to become the first German side since Schalke 04 in 1997 to win the competition.

Their manager Giovanni van Bronckhorst was seeking to become the first Dutch to win a European trophy since Dick Advocaat with Zenit Saint Petersburg in the 2008 UEFA Super Cup; they were qualified after defeating Rangers in the year's UEFA Cup final.

The logo of the 2022 UEFA Europa League Final was unveiled at the group stage draw on 27 August 2021 in Istanbul.

Srđan Jovanović of Serbia served as the fourth official, while Dutchman Pol van Boekel was appointed as the video assistant referee.