Nathan Aspinall was the defending champion after his 8–4 win over Michael Smith in the 2019 final, but he was not invited to take part in this tournament.

[1] Smith won his second World Series title after defeating Michael van Gerwen 8–4 in the final.

The PDC announced the 8 players who would be their elite representatives at the event on 11 April 2022, including Fallon Sherrock, who was denied her chance to appear on the 2020 World Series of Darts circuit, owing to the COVID-19 pandemic.

[3] The North American qualifiers consisted of their four PDC Tour Card holders (Jeff Smith, Danny Baggish, Matt Campbell and Jules van Dongen), plus four spaces at the CDC qualifier in Indianapolis on May 13.

[4] The draw was made on 1 June in Times Square by Rod Harrington.