The incumbent was Republican Nancy Mace, who flipped the district and was elected with 50.6% of the vote in 2020.

Joe Wilson Republican Joe Wilson Republican The 2nd district is located in central South Carolina and spans from Columbia to the South Carolina side of the Augusta, Georgia metropolitan area, including North Augusta.

[1] Duncan was not opposed in the general election, as the state Democrats did not put up a candidate.

[56] Lee Turner organized a write-in campaign for the seat, after court ruling that State Democrats could not place another candidate on the ballot.

Ralph Norman Republican Ralph Norman Republican The 5th district is located in northern South Carolina and encompasses the southern suburbs and exurbs of Charlotte, including Rock Hill.

[1] During the district's Republican primary, Rice was defeated by state representative Russell Fry, who went on to win the general election with 64.8% of the vote.