The 2022 Vanderbilt Commodores baseball team represented Vanderbilt University in the 2022 NCAA Division I baseball season.

The Commodores played their home games at Hawkins Field.

They hosted the 2021 Nashville Regional and finished 3–0.

The Commodores then hosted East Carolina in the Nashville Super Regional, winning the first two games to advance to the College World Series.

The Commodores advanced to the Championship Series of the CWS, finishing as Runner-up to Mississippi State.