The 2022 Wake Forest Demon Deacons football team represented Wake Forest University during the 2022 NCAA Division I FBS football season.

The Demon Deacons played their home games at Truist Field at Wake Forest in Winston–Salem, North Carolina, and competed as members of the Atlantic Coast Conference.

They were led by head coach Dave Clawson, in his ninth season.

Wake Forest announced its 2022 football schedule on January 12, 2022.

The Demon Deacons will host ACC foes Clemson, Boston College, North Carolina, and Syracuse and will travel to Florida State, Louisville, NC State and Duke.