The Tigers played their home games at Faurot Field in Columbia, Missouri, and competed in the Eastern Division of the Southeastern Conference (SEC).

They were led by third-year head coach Eliah Drinkwitz.

The Tigers signed the #15 ranked recruiting class (according to Rivals) prior to the 2022 season, headlined by wide receiver Luther Burden III from East St. Louis, Illinois and quarterback Sam Horn from Suwanee, Georgia.

[1] Missouri and the SEC announced the 2022 football schedule on September 21, 2021.

[7][8] Roster Last update: August 26, 2022 at Faurot Field • Columbia, Missouri at Bill Snyder Family Stadium • Manhattan, Kansas at Jordan–Hare Stadium • Auburn, Alabama at Faurot Field • Columbia, Missouri at Ben Hill Griffin Stadium • Gainesville, FL