The team qualified for the playoffs following their 12th game of the season after defeating the Saskatchewan Roughriders in the Labour Day Classic on September 4, 2022.

[1] The team then clinched first place in the division in week 18 following their victory over the Edmonton Elks on October 8, 2022.

[2] The Blue Bombers reached the 109th Grey Cup, but were not able to perform the three-peat and lost to the Toronto Argonauts 24–23.

[6] The Blue Bombers were scheduled to have the last selection in each of the eight rounds of the draft after winning the Grey Cup in the previous season.

[7] However, the team had two fewer selection after acquiring Cameron Lawson from the Montreal Alouettes in a trade for a first-round pick and Sergio Castillo from the BC Lions for a third-round pick.