The men's 110 metres hurdles at the 2022 World Athletics Championships was held at the Hayward Field in Eugene on 16 and 17 July 2022.

[1] The favored athletes, including reigning Olympic Champion Hansle Parchment, world leader and third fastest of all time Devon Allen, and defending world champion Grant Holloway, all qualified for the final.

Shane Brathwaite hit the sixth hurdle and abandoned his attempt to clear the next.

[citation needed] Before the competition records were as follows:[2] The standard to qualify automatically for entry was 13.32.

[3] The event schedule, in local time (UTC−7), was as follows: The first 4 athletes in each heat (Q) and the next 4 fastest (q) qualify to the semi-finals.