Jamaica competed at the 2022 World Athletics Championships in Eugene, United States, from 15 to 24 July 2022.

[1] On 17 July 2022, Jamaica achieved its first medal sweep at the World Athletics Championships after Shelly-Ann Fraser-Pryce, Shericka Jackson and Elaine Thompson-Herah won gold, silver and bronze, respectively in the women's 100 metres event.

[5] The final entry list published by World Athletics consigned 65 athletes for Jamaica, with Akeem Bloomfield being transferred from the 4 × 400 metres relay mixed team to the men's 200 metres event and being replaced by Demish Gaye and Rusheen McDonald.

[1] Kemar Bailey-ColeAckeem BlakeYohan BlakeConroy JonesOblique SevilleJelani Walker Nathon AllenKarayme BartleyAnthony CoxJavon FrancisJevaughn PowellChristopher Taylor Remona BurchellShelly-Ann Fraser-PryceShericka JacksonKemba NelsonElaine Thompson-HerahBriana Williams Roneisha McGregorCandice McLeodStephenie Ann McPhersonNatalliah WhyteStacey-Ann WilliamsCharokee Young Junelle Bromfield (W)Demish Gaye (M)Tiffany James (W)Rusheen McDonald (M)Gregory Prince (M) However, Javon Francis (men's 4 x 400), Rusheen McDonald and Gregory Prince (both in mixed 4 x 400) had no participation.

Oblique Seville was originally named in the quartet for the preliminaries of the men's 4 × 100 metres relay,[6] however, he was pulled out due to physical discomforts and was replaced by Conroy Jones.