The men's 400 metres hurdles at the 2022 World Athletics Championships was held at the Hayward Field in Eugene from 16 to 19 July 2022.

[1] The podium from the Olympics, the three fastest athletes of all time, all managed to return to the final, but it was a difficult journey.

Olympic Champion/World Record Holder Karsten Warholm pulled up one hurdle into his first race of the season in Rabat and had been on the mend since.

Silver medalist Rai Benjamin also was nursing injuries but ran well at the American Championships, while bronze medalist Alison dos Santos was scorching the tracks of the Diamond League setting a world leading time of 46.80 in Stockholm, a time only bettered in Olympic finals by Kevin Young, Warholm and Benjamin.

[3] The event schedule, in local time (UTC−7), was as follows: The first 4 athletes in each heat (Q) and the next 4 fastest (q) qualify to the semi-finals.