The women's 400 metres hurdles at the 2022 World Athletics Championships was held at the Hayward Field in Eugene, Oregon, United States, from 19 to 22 July 2022.

The podium from the Olympics returned, who were the top three in history from that race, except that Sydney McLaughlin had improved upon her own world record at the American Championships on this track en route to qualifying for these Championships.

The Olympic bronze medalist Femke Bol is even younger than McLaughlin.

McLaughlin continued to charge, 13.66 for the final 100m, crossing the line 11 metres ahead of Bol with a new world record of 50.68.

[7] Since 2019, when Yuliya Pechonkina's world record had stood for almost 16 years, first Muhammad and now McLaughlin have taken one and two thirds seconds off the former mark, with McLaughlin after this race 0.9, almost a full second clear of Muhammad.