The women's 4 × 100 metres relay at the 2022 World Athletics Championships was held at the Hayward Field in Eugene on 22 and 23 July 2022.

[1] Before the competition records were as follows:[2] The standard to qualify automatically for entry was to finish in the first 10 at 2021 World Relays, completed by 6 2021-2022 top lists' teams.

[3] The event schedule, in local time (UTC-7), was as follows: The first three in each heat (Q) and the next two fastest (q) qualified for the final.

[4][5] The final started on 23 July at 19:30.

[6][7][8]