Incumbent Liz Cheney was criticized by former president Donald Trump and his supporters mainly for her vote to impeach him, as well as refusing to object to the certification of the electoral college results in the 2020 presidential election.

[2] Shortly after her impeachment vote, Trump and allies stated that they would work together to back and endorse a primary challenger to Cheney before the 2022 election.

[3] Incumbent Republican governor Mark Gordon ran for re-election, and won.

[2] Incumbent Republican Wyoming Secretary of State Edward Buchanan initially run for re-election, but later chose not to seek a second term.

Incumbent Republican Wyoming State Auditor Kristi Racines won re-election without opposition.