[10] Throughout South East Queensland and the Wide Bay–Burnett, almost one thousand schools were closed in response to the flooding,[11] evacuations took place[12] and the public were advised to avoid non-essential travel.

[13] Food shortages were reported across the region, due to the ensuing supply chain crisis as well as affecting communities in outback Queensland.

Substantial infrastructure damage was caused to the Kedron Brook Floodway attributable to the 1,000 mm of rain that fell in its catchment over the 72 hour period of the floods.

[26] On the 28 February, a river crane for the Kangaroo Point Bridge broke free of its mooring, causing the evacuation of apartment and office buildings along Eagle Street and the area of Howard Smith Wharves.

[35] On 23 February 2022, freight train Y279, operated by Aurizon derailed at approximately 3:30am due to flash flooding that had resulted in a track washout at the 149.020km point just south of Traveston.

[36] On the morning of 28 March, Emergency Services were called to a submerged vehicle in Toowoomba where a man and several dogs had drowned due to the flooding.

[41] Community groups also stepped in to fill gaps in the state and federal governments' response, helping to clear and clean flood damaged houses while providing food and shelter.

[46] On 8 March, another heavy deluge inundated streets in Lansvale, Bass Hill, Bankstown, Liverpool and Wisemans Ferry, in addition to two people being found dead in a storm canal at Wentworthville.

[49][50] In the Upper North Shore, the Roseville Bridge was flooded, in addition to a portion of a ceiling at Bondi Junction Westfield collapsing.

[51] On 7 April, the floods forced Picton, New South Wales to be placed under an evacuation warning as the Stonequarry Creek continued to rise.

Opposition Leader Anthony Albanese criticised the government's handling of bringing in the Australian Defence Force (ADF), saying, "Clearly, there have been issues here with people who were on the roofs of places for a long period of time.

Although Defence minister Peter Dutton and Dominic Perrottet defended the timing of the ADF's arrival, contending that many parts of the area were inaccessible due to inundating floodwaters.

Insurance Council of Australia figures calculated the cost of claims from the disaster was A$1.45 billion as of 7 March, but it was expected to rise once the extent of the damage is known.

Despite the aid efforts, there was rising criticism from those impacted by the floods that the government was too slow to act in sending in defence troops to help them.

The event featured popular Australian musicians who performed to raise money, such as, Tones and I, Jimmy Barnes, Delta Goodrem, Jon Stevens, Vanessa Amorosi, Hunters and Collectors, The Living End, Casey Donovan and Sheppard.

The hosts included Seven's Natalie Barr, David Koch, Sonia Kruger and Mark Ferguson; Nine's Scott Cam, Sylvia Jeffreys, Andy Lee and Peter Overton; and 10's Carrie Bickmore, Dr. Chris Brown, Amanda Keller and Osher Günsberg.