Beginning on July 24, 2022, and lasting for a week, many flash flooding events hit several areas of the United States.

[2][10][11][12][13][14] Late July 28, another unprecedented flash flooding event occurred in Las Vegas after parts of the city saw over an inch of rainfall.

[5] On the morning of July 26, the Weather Prediction Center (WPC) issued a moderate risk outlook for excessive rainfall over portions of eastern Missouri and southern Illinois and Indiana associated with an expected band of training thunderstorms over the region.

Additionally, more than 6 inches (150 mm) of rain fell in the town of Mexico in central Missouri, with similar rainfall totals being reported in southern Illinois.

[22] Training thunderstorms began to form over Eastern Kentucky during the early hours of July 27, producing heavy rainfall periodically throughout the day.

[18] During the late evening and overnight hours, a more substantial band of heavy rain and thunderstorms moved west to east along a stalled frontal boundary, resulting in subsequent extreme flooding across the counties of Perry, Knott, Breathitt, Letcher, Leslie, Clay, Owsley, Wolfe, Harlan, Johnson, Magoffin, Floyd, and Pike.

Flooding was also reported in Southwest Virginia, in the areas of Wise and Dickenson counties, and the independent city of Norton, which are along the Kentucky border.

On the morning of July 28, the WPC issued a moderate risk outlook for excessive rainfall over portions of Central and Eastern Kentucky and West Virginia.

[23][24][25] On the morning of July 29, the WPC issued a moderate risk outlook for excessive rainfall, but shifted it into Eastern Kentucky and almost all of West Virginia.

[25] On the morning of July 31, a third moderate risk outlook for excessive rainfall was issued by the WPC over portions of Eastern Kentucky,[26] with more flooding occurring that night over the same areas as four days earlier.

Near Kingman, over 1 inch (25 mm) of rain fell in approximately 15 minutes on July 31, associated with widespread thunderstorm activity over both states and southern Nevada.

[30] Also on August 2, central Mississippi, including parts of Madison, Yazoo, Holmes, and Attala counties, received as much as 8–10 inches (200–250 mm) of rainfall, causing flooding that impacted roads and homes.

[31][32] On the morning of August 7, WPC issued a moderate risk for excessive rainfall across portions of northeastern Iowa and southern Wisconsin.

[41] In Belleville, which received approximately 8 inches (200 mm) of rain, multiple roadways were closed due to high water, with a section of one street being washed away.

This, combined with additional rainfall and flooding on July 28, led to a state of emergency being declared by Governor Jim Justice for six counties: Mingo, McDowell, Fayette, Greenbrier, Logan, and Wyoming.

[18] The Kentucky Court of Justice closed the judicial centers in Floyd, Letcher, Magoffin, and Perry counties due to the extreme flooding.

[51] Kentucky cities severely affected by the floods include Hazard, Jackson, Paintsville, Prestonsburg, Martin, Pikeville, Hindman, Whitesburg, Fleming-Neon, and Jenkins.

Evacuations were ordered in the downtown areas of cities that were severely flooded including Hazard, Fleming-Neon, Jenkins, Martin, Pound, and Clintwood, Virginia.

[52] The North Fork of the Kentucky River set record high crests in Whitesburg and Jackson,[18] and over 33,000 customers lost electricity.

[53] Late on July 28 and into July 29, part of the city of Jackson was evacuated and KY 15 was closed after officials became concerned that water from the North Fork River would top Panbowl Dam along KY 15 and potentially flood approximately 110 homes, 13 businesses, and other structures around Panbowl Lake, although the river began receding before the dam was overtopped.

Casinos on the Strip that were impacted included Caesars Palace and Planet Hollywood, with water pouring through parts of the ceilings into the buildings.

Las Vegas Boulevard and Main Street, especially in downtown and the area of the Strip, were covered in water, creating traffic problems.

[68] Rain beginning on July 25 in the Flagstaff, Arizona area associated with the monsoon season led to increased flash flooding concerns throughout the week, due in part to the burn scars from the recent wildfires.

[28][29] Areas near Canton, Mississippi also received very heavy rainfall on August 2, leading to flash flooding that trapped people in homes in Madison County.

Numerous people were rescued by fire department crews from houses and offices after some areas received up to 8 inches (200 mm) of rainfall in a few hours.

[4] Starting late on August 21, 2022, and going into the next morning, a significant flash flooding event occurred in the Dallas–Fort Worth metroplex in Texas, killing one person and injuring four others.

[86] On the morning of August 21, the Weather Prediction Center (WPC) issued a moderate risk for excessive rainfall for North and Northeast Texas.

CDT on August 22, the storms associated with the flooding event produced an EF1 tornado that impacted Smith County, approximately 100 miles (160 km) east of downtown Dallas.

"[9] On July 29, President Joe Biden declared that a major disaster existed in Kentucky and ordered federal aid to supplement state and local recovery efforts in the areas affected by severe storms, flooding, landslides, and mudslides.

[109] Some residents in Kentucky were stuck in their homes, unable to leave because of washed out roads and bridges, leading to over 420 people being rescued by helicopter or boat.