[7] On March 29, Angel City announced the transfer and signing of Mexican national team forward and San Diego native Scarlett Camberos from Club América of Mexico's Liga MX Femenil for an undisclosed fee.

[8][9] During a match against Orlando Pride on April 2, Angel City forward Simone Charley suffered a ruptured Achilles tendon.

On April 7, assistant coach Melissa Phillips accepted the role of manager at Brighton & Hove Albion of the English Women's Super League.

[11] On April 17, Angel City announced the signing of United States national team midfielder Julie Ertz to a one-year contract.

[17] On May 27, Angel City FC suffered its worst loss since June 3, 2022, losing 1–4 to OL Reign in Seattle despite going up early on a Claire Emslie goal scored directly from a corner.

[18] Angel City closed the month with a May 31 Challenge Cup loss at Portland Thorns FC, fighting back from a 0–2 deficit to equalize in the second half but conceding a goal in the 3rd minute of second-half stoppage time to lose 2–3.

[24] On June 25, Angel City was able to keep their undefeated streak going in a 0–0 draw against Houston Dash in the last match before players who had been called up for the 2023 FIFA Women's World Cup in Australia and New Zealand departed.

[25] Four Angel City players, Jun Endo, Ali Riley, Julie Ertz, and Alyssa Thompson had been selected by their respective national teams to represent their countries at the World Cup.

[30] On July 29, Angel City returned to the pitch in the 2023 Challenge Cup in a match against Portland Thorns at home which was won 2–1 a brace from Savannah McCaskill as well as penalty save against Olivia Moultrie by Angelina Anderson in her first professional appearance to secure the win.

[32] On August 5, Angel City traveled to play rivals San Diego Wave in their final match of the 2023 Challenge Cup group stage which finished in a 1–1 draw.

[34] On August 17, Angel City announced that they had re-signed NTR players Elizabeth Eddy and Kelsey Hill to new contracts that would keep them at the club until the end of the season.

[35] On August 20, in the first NWSL regular season match since the World Cup break, Angel City traveled to play Racing Louisville FC which ended in a 1–1 draw.

[42] On October 15, the final day of the NWSL regular season, Angel City had the chance to secure their first spot in the playoffs in their match against the defending champions Portland Thorns.

Angel City went on to win the game 5–1 in their biggest victory ever and successfully secured a spot in the NWSL Playoffs as they eventually finished fifth overall with a record of 8–7–7 despite being in 11th of 12th place when former head coach Freya Coombe was fired in June.

On October 20, Angel City competed in their first NWSL Playoff Match against OL Reign at Lumen Field in Seattle which ended in a 1–0 defeat after a late goal from Veronica Latsko.

[47] Under head coach Freya Coombe, Angel City deploy a four-player backline with a focus on possession and building play from the back.